1) Drug consult – PICO Questions
In a 55-year old male with infective endocarditis (IE) caused by Enterococcus faecalis, is Ampicillin + Ceftriaxone (AC) as safe, efficacious and/or with fewer side effects as compared to Ampicillin + Gentamicin (AG)? Write background, recommendations and use references below to AMA cite,
i) Background
ii)Recommendation
iii) AMA Citations
References to use below
Rafei AE, Desimone DC, Narichania AD., et al. Comparison of Dual ?-Lactam therapy to penicillin-aminoglycoside combination in treatment of Enterococcus faecalis infective endocarditis. J Infection. 2018;77(5):398-404. Fernández-Hidalgo N, Almirante B, Gavaldà J., et al. Ampicillin Plus Ceftriaxone Is as Effective as Ampicillin Plus Gentamicin for Treating Enterococcus faecalis Infective Endocarditis. Clin Infect Dis. 2013;56(9):1261-1268. Clinical Pharmacology Web site. https://www.clinicalpharmacology-ip.com/Forms/Monograph/monograph.aspx?cpnum=275&sec=monadve&t=0. Accessed January 25, 2019. Dynamed Website