Usefulness of Schild plot

1) What is the usefulness of the Schild plot when considering antagonists2) What are “spare receptors”? How can you determine spare receptors experimentally? What do you think could be a reason why spare receptors exist? 3) Define affinity, efficacy, and potency Briefly explain the relationship among them. 4) Briefly explain the concept of inverse agonism in your words. What is the prerequisite of having inverse agonist? 5) Briefly describe the allosteric theory of drug action in your words.